Synthesis of New Ester Linked 1,4-Disubstituted 1,2,3-Bistriazoles and their Antibacterial Evaluation
Wedad aladiwish Abstract : A new serial of 1,4-disubstituted 1,2,3-bistriazoles 5a-f compounds was synthesized via cycloaddition of various bisalkyne 4a-c with 1-azido-4-nitrobenzene 2a and 1-azido-4-methylbenzene 2b. The click reaction the cycloaddition between bisalkynes and the azides carried out in water- tetrahydrofuran (THF) with mixture containing copper sulfate cu (I) as the catalyst and sodium ascorbate