Wedad aladiwish
Abstract :
A new serial of 1,4-disubstituted 1,2,3-bistriazoles 5a-f compounds was synthesized via cycloaddition of various bisalkyne 4a-c with 1-azido-4-nitrobenzene 2a and 1-azido-4-methylbenzene 2b. The click reaction the cycloaddition between bisalkynes and the azides carried out in water- tetrahydrofuran (THF) with mixture containing copper sulfate cu (I) as the catalyst and sodium ascorbate as the base. Synthesized 1,4-disubstituted 1,2,3-bistriazoles were characterized by IR, 1H NMR, and 13C NMR techniques. Some of selected compounds were evaluated for antibacterial activity against three bacterial strains:.Gram-positive bacteria Staphylococcus aureus (S. aureus) and Gram-negative bacteria Escherichia coli (E. coli) and Acinetobacter baumannii (A. baumannii), using the disc diffusion method. The results revealed notable antibacterial efficacy. The highest inhibition zone was observed against (A. baumannii), likely due to differences in the bacterial cell wall structure.